Yu G D, Wei X P, Zhang H Q, Xu S, Yin Q Z, Tang P L, Qian Z M
Laboratory of Neurobiology, Suzhou Medical College.
Sheng Li Xue Bao. 1997 Jun;49(3):314-20.
The effect of dorsal raphe nucleus (DR) stimulation on the unit discharge of suprachiasmatic nucleus (SCN) neurons was studied and analyzed pharmacologically in the Wistar rats. Experimental results showed that DR stimulation could significantly inhibit the light-induced discharge of SCN neurons. Pharmacologically, this inhibition could be enhanced by monoamine oxidase inhibitor pargyline, attenuated by 5-hydroxytryptamine (5-HT) synthesis inhibitor parachlorophenylalanine and blocked by 5-HT receptor antagonist cyproheptadine. It was suggested that the inhibitory effect of DR stimulation on the light-sensitive SCN neuron discharge might be mediated by 5-HT.
在Wistar大鼠中，研究并通过药理学方法分析了中缝背核（DR）刺激对视交叉上核（SCN）神经元单位放电的影响。实验结果表明，DR刺激可显著抑制SCN神经元的光诱导放电。从药理学角度来看，单胺氧化酶抑制剂优降宁可增强这种抑制作用，5-羟色胺（5-HT）合成抑制剂对氯苯丙氨酸可减弱这种抑制作用，5-HT受体拮抗剂赛庚啶可阻断这种抑制作用。这表明DR刺激对光敏感的SCN神经元放电的抑制作用可能由5-HT介导。
