Gu R M, Sun M Z, Li Y R, Zhang J Y, Han W M, Liu G
Department of Physiology, Harbin Medical University.
Sheng Li Xue Bao. 1997 Jun;49(3):321-6.
The characteristics of glass microelectrode recorded electrical activity of nociceptive neurons in the caudate nucleus elicited by microinjection of GABA and blockage by picrotoxin (PIC) were studied in 53 Wistar rats. The results showed that GABA (25, 50, 100 micrograms/2 microliters every 2 min) inhibited the activity of pain excitation neurons (PEN), as shown by decreased frequency and increased latency, but enhanced the activity of pian, inhibition neurons (PIN), as shown by shortened duration and increased discharge frequency. Both activities are highly dose-dependent and could be blocked by PIC (i.p. 250 micrograms, 1 ml/1 min).
在53只Wistar大鼠中研究了玻璃微电极记录的尾状核伤害性神经元电活动的特征，该电活动由微量注射γ-氨基丁酸（GABA）引发，并被印防己毒素（PIC）阻断。结果表明，GABA（每2分钟25、50、100微克/2微升）抑制痛觉兴奋神经元（PEN）的活动，表现为频率降低和潜伏期延长，但增强痛觉抑制神经元（PIN）的活动，表现为持续时间缩短和放电频率增加。这两种活动都高度依赖剂量，并且可被PIC（腹腔注射250微克，1毫升/1分钟）阻断。
