一种量化啮齿动物震颤的简单方法。

A simple method for quantifying tremor in rodents.

作者信息

Remington G, Anisman H

出版信息

Pharmacol Biochem Behav. 1976 Jun;4(6):721-3. doi: 10.1016/0091-3057(76)90226-4.

Abstract

A simple and accurate device to evaluate frequency and intensity of involuntary tremor is described. Discrete and quantifiable measures of tremor could be obtained in terms of vertical (i.e., absolute effects at a given time) and horizontal (i.e. temporal) changes. The technique was evaluated employing dosages of physostigmine 0.1-0.7 mg/kg. Applications to other behavioral indices, such as locomotor activity and wet-dog shakes, are discussed.

摘要

本文描述了一种用于评估非自愿性震颤频率和强度的简单而精确的装置。可以根据垂直方向（即给定时间的绝对效应）和水平方向（即时间）的变化获得离散且可量化的震颤测量值。该技术采用0.1 - 0.7mg/kg剂量的毒扁豆碱进行评估。还讨论了该技术在其他行为指标上的应用，如运动活动和湿狗样抖动。