[Enzymatically cleavable specific transport forms of cancerostatics. 3. 4-/N.N-bis-(2-chlorethyl)-amino/-derivatives of phenyl-O-beta-D-cellobiosids and pyrocatechol-bis-/O-beta-D-cellobiosids].
作者信息
Schwabe K, Graffi A, Redslob J, Hülsmann W, Butschak G
出版信息
Pharmazie. 1976 Jul;31(7):438-41.
PMID:981295
Abstract
摘要
相似文献
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[Biological effects of 4-[N.N-bis-(2-chlorethyl)-amino]-phenyl-O-beta-D-glucopyranosiduronic acid methylesters].
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[Aromatic N-mustard compounds. 1. Derivatives of 3-N, N-bis-(2-chlorethyl)amino-4-methylbenzoid acid].[芳香族氮芥化合物。1. 3-N，N-双（2-氯乙基）氨基-4-甲基苯甲酸的衍生物]
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Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.在基因导向酶前药治疗系统中，可被羧肽酶G2裂解产生3,5-二氟苯酚和苯胺氮芥的前药之间，生物学参数存在显著差异。
J Med Chem. 2004 May 6;47(10):2651-8. doi: 10.1021/jm030966w.
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[Synthesis of a potential metabolite of the carcinostatic bendamustin (Cytostasen)].[抗癌药苯达莫司汀（Cytostasen）潜在代谢物的合成]
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Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1.新型化疗药物β-D-葡萄糖基异磷酰胺氮芥（D-19575）进入肿瘤细胞的转运是由钠-葡萄糖共转运体SAAT1介导的。
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2914-9. doi: 10.1073/pnas.95.6.2914.
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