Burgoyne P S
Laboratory of Developmental Genetics, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK.
Semin Cell Dev Biol. 1998 Aug;9(4):423-32. doi: 10.1006/scdb.1998.0228.
As long ago as 1931 Fisher outlined the reasons for the accumulation of male 'benefit genes' (e.g. male fertility factors) on the Y chromosome, but it was over four decades later that a study of men with partial Y chromosome deletions revealed that a factor essential for male fertility was present on the human Y. Today, the Y deletion interval containing this 'Azoospermia Factor' (AZF) has been subdivided into three subintervals associated with different degrees of spermatogenic impairment. Furthermore, three deletion intervals have been identified on the mouse Y that impact on the spermatogenic process. This review examines these deletion intervals in mouse and man and summarises progress towards identifying candidate genes for their respective spermatogenic functions.
早在1931年，费希尔就概述了Y染色体上男性“有益基因”（如男性生育因子）积累的原因，但40多年后，一项对部分Y染色体缺失男性的研究表明，人类Y染色体上存在一种对男性生育至关重要的因子。如今，包含这个“无精子症因子”（AZF）的Y染色体缺失区间已被细分为三个与不同程度生精障碍相关的子区间。此外，在小鼠Y染色体上已确定了三个影响生精过程的缺失区间。这篇综述研究了小鼠和人类中的这些缺失区间，并总结了在确定其各自生精功能候选基因方面取得的进展。
