Freed E O
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0460, USA.
Virology. 1998 Nov 10;251(1):1-15. doi: 10.1006/viro.1998.9398.
The Gag proteins of HIV-1, like those of other retroviruses, are necessary and sufficient for the assembly of virus-like particles. The roles played by HIV-1 Gag proteins during the life cycle are numerous and complex, involving not only assembly but also virion maturation after particle release and early postentry steps in virus replication. As the individual Gag domains carry out their diverse functions, they must engage in interactions with themselves, other Gag proteins, other viral proteins, lipid, nucleic acid (DNA and RNA), and host cell proteins. This review briefly summarizes our current understanding of how HIV-1 Gag proteins function in the virus life cycle.
与其他逆转录病毒一样，HIV-1的Gag蛋白对于病毒样颗粒的组装是必需且足够的。HIV-1 Gag蛋白在生命周期中发挥的作用众多且复杂，不仅涉及组装，还包括颗粒释放后的病毒体成熟以及病毒复制的早期进入后步骤。由于各个Gag结构域执行其不同功能，它们必须与自身、其他Gag蛋白、其他病毒蛋白、脂质、核酸（DNA和RNA）以及宿主细胞蛋白进行相互作用。本综述简要总结了我们目前对HIV-1 Gag蛋白在病毒生命周期中如何发挥功能的理解。
