Chudler E H
Department of Anesthesiology, Box 356540, University of Washington, Seattle, WA 98195-6540, USA.
Brain Res. 1998 Nov 23;812(1-2):283-8. doi: 10.1016/s0006-8993(98)00971-8.
To investigate the possible mechanisms by which neurons in the caudate-putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neurons were capable of encoding noxious thermal stimuli and 79% of these thermally responsive neurons also responded to noxious mechanical stimuli. Thermally responsive neurons were activated during the phasic rise and fall of the thermal shift in addition to the plateau temperature. The ability of CPu and GP neurons to encode noxious thermal stimulation intensity and respond during the dynamic phase of the stimulus suggests that these neurons may contribute to the behavioral response to minimize bodily harm.
为了研究尾状核-壳核（CPu）和苍白球（GP）中的神经元参与疼痛和伤害感受的可能机制，本研究对麻醉大鼠中CPu和GP神经元对非伤害性和伤害性热刺激的反应特性进行了表征。伤害性CPu和GP神经元能够编码伤害性热刺激，并且这些热反应神经元中有79%也对伤害性机械刺激有反应。除了平台期温度外，热反应神经元在热变化的相位上升和下降期间也被激活。CPu和GP神经元编码伤害性热刺激强度并在刺激动态阶段做出反应的能力表明，这些神经元可能有助于产生行为反应以尽量减少身体伤害。
