Chai D, Zhou Z N
Institute of Physiology, Chinese Academy of Sciences, Shanghai.
Sheng Li Xue Bao. 1997 Oct;49(5):497-503.
The effects of hyoxia and reoxygenation on myoglobin (Mb), cAMP, myocardial contractility and the effects of theophylline (an inhibitor of phosphodiesterase), procaine (an inhibitor of SR calcium release) on Mb expression were studied in cultured myocytes under hypoxic condition. Our results showed that hypoxia increased the Mb expression, but decreased cAMP and myocardial contractility. All these effects of hypoxia were recovered upon reoxygenation. The increase of Mb expression requires the participation of intracellular calcium and cAMP.
在缺氧条件下，研究了缺氧和复氧对培养心肌细胞中肌红蛋白（Mb）、环磷酸腺苷（cAMP）、心肌收缩力的影响，以及茶碱（一种磷酸二酯酶抑制剂）、普鲁卡因（一种肌浆网钙释放抑制剂）对Mb表达的影响。我们的结果表明，缺氧增加了Mb的表达，但降低了cAMP水平和心肌收缩力。复氧后，缺氧的所有这些影响均得到恢复。Mb表达的增加需要细胞内钙和cAMP的参与。
