Chen L H, Zhou Z N
Shanghai Institute of Physiology, Chinese Academy of Sciences.
Sheng Li Xue Bao. 1997 Oct;49(5):521-5.
The difference of morphological injury between rabbit aorta and pulmonary artery was compared after the animal was exposed to the altitude 5 km (PO2 = 10.8 kPa) for 24 h. Hypoxia caused subendothelial edema, increased vacuoles and injured mitochondria and endoplasmic reticulums in both kinds of endothelial cells. The impairment of pulmonary artery was obviously more severe than aorta and its smooth muscle cells were also affected. Forthermore, the exposure increased mitochondria in pulmonary artery endothelial cells. Bubbled with a mixture air of 95% N2-5% CO2 (PO2 = 4 kPa) led to an increase of pulmonary in tension, while hypoxia to the same extent induced aorta relaxation. These results indicate that hypoxia produces the differential effects on these two kinds of vessels, providing a possible explanation for the production of hypoxic pulmonary hypertension.
将动物暴露于海拔5千米（PO2 = 10.8千帕）24小时后，比较兔主动脉和肺动脉形态学损伤的差异。缺氧导致两种内皮细胞出现内皮下水肿、空泡增加、线粒体和内质网损伤。肺动脉的损伤明显比主动脉严重，其平滑肌细胞也受到影响。此外，暴露增加了肺动脉内皮细胞中的线粒体。用95% N2 - 5% CO2的混合气体（PO2 = 4千帕）鼓泡导致肺张力增加，而同等程度的缺氧则诱导主动脉舒张。这些结果表明，缺氧对这两种血管产生不同的影响，为缺氧性肺动脉高压的产生提供了一种可能的解释。
