Folstein S E, Bisson E, Santangelo S L, Piven J
Department of Psychiatry, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
J Autism Dev Disord. 1998 Oct;28(5):439-45. doi: 10.1023/a:1026008606672.
Although autism is clearly inherited, it may be challenging to find the genes involved: The mechanism of inheritance is unknown, families with an autistic child are usually small, parent-child pairs are rare, and a fairly large number of genes may be involved, some or all of which may have a small effect on the phenotype. We discuss several strategies for finding genes, all of which may be used in combination to find the relevant genes.
尽管自闭症显然是遗传性的，但要找到相关基因可能具有挑战性：遗传机制尚不清楚，有自闭症孩子的家庭通常规模较小，亲子对很少见，而且可能涉及相当多的基因，其中一些或全部可能对表型有微小影响。我们讨论了几种寻找基因的策略，所有这些策略都可以结合使用以找到相关基因。
