Ahmed A, Hafiz S, Ahmed Q T, Majeed H, Syed S
Ziauddin Medical University, Karachi.
J Pak Med Assoc. 1998 Jun;48(6):158-61.
Of the 43 Aeromonas spp. isolated from various clinical samples 94% isolates were Beta-lactamase producers. The isolates were tested for sensitivity by disc diffusion method which is commonly used in Pakistan. MIC was determined by using Epsilometer test (E-test) method. More than 80% isolates were sensitive to cephalosporins and quinolones. However, resistance to commonly used antibiotics was very high, 94% isolates were resistant to ampicillin which corresponds to the betalactamase production. More than 60% of the isolates were resistant to cotrimoxazole and 40% to chloramphenicol, hence quinolones and cephalosporins appear to be the drugs of choice for treating serious Aeromonas infections. The MIC range of Aeromonas was best for cefotaxime < 0.06 - 1.0 ug/ml. MIC 90 for cefotaxime was 0.50 ug/ml, for imipenem 0.25 ug/ml and for ciprofloxacin 2.0 ug/ml.
从各种临床样本中分离出的43株气单胞菌属细菌中，94%的分离株产β-内酰胺酶。采用巴基斯坦常用的纸片扩散法对分离株进行敏感性测试。通过E试验法测定最低抑菌浓度（MIC）。超过80%的分离株对头孢菌素和喹诺酮类敏感。然而，对常用抗生素的耐药性很高，94%的分离株对氨苄西林耐药，这与β-内酰胺酶的产生相对应。超过60%的分离株对复方新诺明耐药，40%对氯霉素耐药，因此喹诺酮类和头孢菌素类似乎是治疗严重气单胞菌感染的首选药物。气单胞菌的MIC范围以头孢噻肟最佳，为<0.06 - 1.0μg/ml。头孢噻肟的MIC90为0.50μg/ml，亚胺培南为0.25μg/ml，环丙沙星为2.0μg/ml。
