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一例移植后肾动脉狭窄:氯沙坦在肾图检查中是否比卡托普利更准确?

A case of renal artery stenosis after transplantation: can losartan be more accurate than captopril renography?

作者信息

Fuster D, Paz Marco M, Setoain F J, Oppenheimer F, Lomeña F

机构信息

Nuclear Medicine Department, Hospital Clinic of Barcelona, Spain.

出版信息

Clin Nucl Med. 1998 Nov;23(11):731-4. doi: 10.1097/00003072-199811000-00001.

DOI:10.1097/00003072-199811000-00001
PMID:9814557
Abstract

Hypertension is a common complication observed after renal transplantation. If the hypertension is of renovascular origin, transluminal angioplasty or surgery of the renal artery stenosis can lead help cure the hypertension. The blood pressure of a 31-year-old man who underwent renal transplantation 2 years earlier gradually increased. Arteriography showed stenosis (>80%) in the two branches of the renal artery. To help confirm the presence of renovascular hypertension, captopril renography was performed but showed no significant changes compared with baseline renography. Renography was performed again after losartan administration and showed impaired renal function. In this case, losartan renography was more useful than captopril in suggesting renovascular hypertension.

摘要

高血压是肾移植后常见的并发症。如果高血压源于肾血管,经腔血管成形术或肾动脉狭窄手术有助于治愈高血压。一名31岁男性在两年前接受了肾移植,其血压逐渐升高。血管造影显示肾动脉的两个分支存在狭窄(>80%)。为了帮助确认肾血管性高血压的存在,进行了卡托普利肾图检查,但与基线肾图相比无明显变化。服用氯沙坦后再次进行肾图检查,结果显示肾功能受损。在这种情况下,氯沙坦肾图在提示肾血管性高血压方面比卡托普利更有用。

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引用本文的文献

1
Losartan renography for the detection of renal artery stenosis: comparison with captopril renography and evaluation of dose and timing.氯沙坦肾图用于检测肾动脉狭窄:与卡托普利肾图的比较及剂量和时间的评估
Eur J Nucl Med Mol Imaging. 2005 Sep;32(9):1064-74. doi: 10.1007/s00259-005-1789-9. Epub 2005 May 5.
2
Reversible renal impairment induced by treatment with the angiotensin II receptor antagonist candesartan in a patient with bilateral renal artery stenosis.血管紧张素II受体拮抗剂坎地沙坦治疗导致双侧肾动脉狭窄患者出现可逆性肾功能损害。
BMC Nephrol. 2001 May 17;2:1. doi: 10.1186/1471-2369-2-1.
3
Therapeutic trials comparing angiotensin converting enzyme inhibitors and angiotensin II receptor blockers.
比较血管紧张素转换酶抑制剂和血管紧张素II受体阻滞剂的治疗试验。
Curr Hypertens Rep. 2000 Aug;2(4):402-11. doi: 10.1007/s11906-000-0045-8.