Mehr R, Perelson A S, Sharp A, Segel L, Globerson A
Dept. of Molecular Biology, Princeton University, New Jersey 08544, USA.
Dev Immunol. 1998;5(4):303-18. doi: 10.1155/1998/65943.
Reconstitution of the T-cell compartment after bone marrow transplantation depends on successful colonization of the thymus by bone-marrow-derived progenitor cells. Recent studies compared the development of syngeneic and allogeneic bone-marrow-derived cells in co-cultures with lymphoid-depleted fetal thymus explants, leading to the discovery of MHC-linked syngeneic developmental preference (SDP) in the thymus. To determine the nature of cell interactions among the bone marrow and thymic elements that might underlie SDP, we analyzed this phenomenon by mathematical modeling. The results indicate that syngeneic mature T cells, responsible for inducing this preference, probably interfere both with the seeding of allogeneic bone-marrow-derived thymocyte progenitors in the thymic stroma and with their subsequent proliferation. In addition, the possibility of augmented death among the developing allogeneic thymocytes cannot be ruled out.
骨髓移植后T细胞区室的重建取决于骨髓来源的祖细胞成功定殖于胸腺。最近的研究比较了同基因和异基因骨髓来源的细胞与淋巴细胞清除的胎儿胸腺外植体共培养时的发育情况，从而发现了胸腺中与主要组织相容性复合体（MHC）相关的同基因发育偏好（SDP）。为了确定可能是SDP基础的骨髓和胸腺成分之间细胞相互作用的性质，我们通过数学建模分析了这一现象。结果表明，负责诱导这种偏好的同基因成熟T细胞可能既干扰异基因骨髓来源的胸腺细胞祖细胞在胸腺基质中的播种，也干扰其随后的增殖。此外，发育中的异基因胸腺细胞死亡增加的可能性也不能排除。
