Clements-Mann M L
Center for Immunization Research, Department of International Health, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.
AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S197-203.
Critical misconceptions about vaccine development have arisen in the context of acquired immunodeficiency syndrome (AIDS) vaccine research. These include: the goal of vaccination; the biological relevance and predictive value of animal models; the meaning of "correlates of protective immunity"; the nature and duration of vaccine-induced immune responses; and the need for multiple, iterative field trials. In this article, lessons from the history of successful vaccine development relevant to these issues are discussed. Clarity about these central issues and adherence to a common vocabulary are important for the process of establishing an appropriate, milestone-driven process for developing safe, effective AIDS vaccines.
在获得性免疫缺陷综合征（艾滋病）疫苗研究背景下，出现了有关疫苗研发的严重误解。这些误解包括：疫苗接种的目标；动物模型的生物学相关性和预测价值；“保护性免疫相关因素”的含义；疫苗诱导免疫反应的性质和持续时间；以及进行多次迭代现场试验的必要性。本文讨论了与这些问题相关的成功疫苗研发历史中的经验教训。明确这些核心问题并坚持使用通用词汇，对于建立一个合适的、以里程碑为驱动的流程来开发安全有效的艾滋病疫苗至关重要。
