Sun W M, Doran S, Jones K L, Ooi E, Boeckxstaens G, Hebbard G S, Lingenfelser T, Morley J E, Dent J, Horowitz M
Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia.
Am J Physiol. 1998 Nov;275(5):G1173-8. doi: 10.1152/ajpgi.1998.275.5.G1173.
The effects of the nitric oxide donor nitroglycerin on gastric emptying and antropyloroduodenal motility were evaluated in nine healthy male subjects (ages 19-36 yr). Antropyloroduodenal pressures were recorded with a manometric assembly that had nine side holes spanning the antrum and proximal duodenum and a pyloric sleeve sensor; gastric emptying was quantified scintigraphically. In each subject, the emptying of 300 ml of 25% glucose labeled with 99mTc was assessed on two separate days during intravenous infusion of either nitroglycerin (5 micrograms/min in 5% dextrose) or 5% dextrose (control). Studies were performed with the subject in the supine position; blood pressure and heart rate were monitored. Nitroglycerin had no significant effect on blood pressure or heart rate. Nitroglycerin slowed gastric emptying (P < 0.02), and this was associated with greater retention of the drink in the proximal stomach (P < 0.05). In both nitroglycerin and control studies, ingestion of the drink was associated with an increase in the number of isolated pyloric pressure waves (P < 0.05) and antral pressure wave sequences (P < 0.05). Nitroglycerin reduced the number of isolated pyloric pressure waves (P < 0.05), basal pyloric pressure (P < 0.05), and the number of antral pressure wave sequences (P < 0. 05), but not the total number of antral pressure waves. The rate of gastric emptying and the number of isolated pyloric pressure waves were inversely related during control (P = 0.03) and nitroglycerin (P < 0.05) infusions. We conclude that in normal subjects, 1) gastric emptying of 300 ml of 25% glucose is inversely related to the frequency of phasic pyloric pressure waves, and 2) nitroglycerin in a dose of 5 micrograms/min inhibits pyloric motility, alters the organization but not the number of antral pressure waves, and slows gastric emptying and intragastric distribution of 25% glucose.
在9名健康男性受试者（年龄19 - 36岁）中评估了一氧化氮供体硝酸甘油对胃排空及胃幽门十二指肠运动的影响。采用一种测压装置记录胃幽门十二指肠压力，该装置有9个侧孔横跨胃窦和十二指肠近端，还有一个幽门套传感器；通过闪烁扫描法定量胃排空情况。在每名受试者中，于静脉输注硝酸甘油（5%葡萄糖中5微克/分钟）或5%葡萄糖（对照）期间，在两个不同日期评估300毫升标记有99mTc的25%葡萄糖的排空情况。研究在受试者仰卧位时进行；监测血压和心率。硝酸甘油对血压或心率无显著影响。硝酸甘油使胃排空减慢（P < 0.02），且这与饮料在胃近端的潴留增加有关（P < 0.05）。在硝酸甘油和对照研究中，摄入饮料均与孤立幽门压力波数量增加（P < 0.05）及胃窦压力波序列增加（P < 0.05）有关。硝酸甘油减少了孤立幽门压力波数量（P < 0.05）、基础幽门压力（P < 0.05）及胃窦压力波序列数量（P < 0.05），但未减少胃窦压力波总数。在对照（P = 0.03）和硝酸甘油输注（P < 0.05）期间，胃排空速率与孤立幽门压力波数量呈负相关。我们得出结论，在正常受试者中，1）300毫升25%葡萄糖的胃排空与阶段性幽门压力波频率呈负相关，2）5微克/分钟剂量的硝酸甘油抑制幽门运动，改变胃窦压力波的组织形式但不改变其数量，并减慢25%葡萄糖的胃排空及胃内分布。
