Kaufmann G R, Cunningham P, Kelleher A D, Zaunders J, Carr A, Vizzard J, Law M, Cooper D A
Centre for Immunology and HIV Medicine Unit, St Vincent's Hospital, and National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia.
J Infect Dis. 1998 Dec;178(6):1812-5. doi: 10.1086/314480.
This study used curve-fitting techniques to detail the dynamics of human immunodeficiency virus (HIV)-1 and its relationship to circulating T lymphocyte changes in a cohort of 41 male patients (mean age 36+/-7 years) infected with HIV-1. The following characteristics of viral kinetics were obtained: virus load peak, 6. 35+/-0.71 log10 RNA copies/mL at 12.2+/-7.1 days; virus load drop from peak, 2.02+/-0.93 log10 copies/mL; viral decay rate from peak, 0.071+/-0.042 log10 RNA copies/mL/day; and steady state virus load, 4.57+/-0.68 log10 copies/mL at 135+/-81 days. Analysis of individual virus load curves revealed highly variable viral kinetics. Although these could be grouped into three distinct patterns, virus load and CD4 lymphocyte counts were similar in all patterns at 12 months, but the interval from infection to achievement of steady state virus load varied significantly.
本研究采用曲线拟合技术，详细分析了41例感染人类免疫缺陷病毒1型（HIV-1）男性患者（平均年龄36±7岁）体内HIV-1的动态变化及其与循环T淋巴细胞变化的关系。获得了以下病毒动力学特征：病毒载量峰值，在12.2±7.1天时为6.35±0.71 log10 RNA拷贝/毫升；病毒载量从峰值下降，为2.02±0.93 log10拷贝/毫升；病毒从峰值的衰减率，为0.071±0.042 log10 RNA拷贝/毫升/天；稳态病毒载量，在135±81天时为4.57±0.68 log10拷贝/毫升。对个体病毒载量曲线的分析显示病毒动力学具有高度变异性。虽然这些曲线可分为三种不同模式，但在12个月时，所有模式下的病毒载量和CD4淋巴细胞计数相似，但从感染到达到稳态病毒载量的间隔差异显著。
