Freibauer C
Department of Clinical Pathology, General Hospital of Mistelbach, Austria.
Wien Klin Wochenschr. 1998 Sep 18;110(17):608-11.
The identification of basal cells by the basal-cell-specific anti-cytokeratin antibody 34 beta E12 has been shown to be useful in the diagnosis of prostate carcinoma. To determine the usefulness of 34 beta E12 in prostate biopsies we examined formalin-fixed needle biopsy specimens. In a 17-month period 796 prostate needle biopsies obtained from 293 patients were evaluated on hematoxylin and eosin stains; all 796 biopsy specimens were immunostained as well. Immunostaining with 34 beta E12 reduced the rate of equivocal cases from 5.1% to 1.0% and additionally offered a means of quality assurance by confirming the diagnoses of 61 prostate carcinomas made on the basis of biopsy specimens.
已证明通过基底细胞特异性抗细胞角蛋白抗体34βE12鉴定基底细胞在前列腺癌的诊断中很有用。为了确定34βE12在前列腺活检中的作用，我们检查了福尔马林固定的针吸活检标本。在17个月的时间里，对从293例患者获得的796份前列腺针吸活检标本进行苏木精和伊红染色评估；所有796份活检标本也进行了免疫染色。用34βE12进行免疫染色将模棱两可病例的发生率从5.1%降至1.0%，此外，通过确认基于活检标本做出的61例前列腺癌诊断，提供了一种质量保证手段。
