Hehrlein C, Bode C, Brachmann J, Kübler W
Medizinische Klinik III, Heidelberg.
Z Kardiol. 1998 Sep;87(9):699-706. doi: 10.1007/s003920050229.
Restenosis is a clinical problem after coronary angioplasty associated with major ischemic events or repeat interventions in 20-50% of the patients undergoing this procedure. Major efforts have been undertaken in the past decade to successfully prevent or treat restenosis but no pharmacologic approach to the problem has as yet been identified to be effective enough in clinical conditions. New strategies to cope with restenosis are targeted by local application of ionizing radiation which markedly reduces cell proliferation after angioplasty in animal experiments. Preliminary clinical trials indicate that endovascular radiation therapy is a safe and effective means to treat restenosis. Randomized, multicenter studies with long follow-up periods are needed to support these early results.
再狭窄是冠状动脉血管成形术后的一个临床问题，在接受该手术的患者中，有20%至50%会出现重大缺血事件或需要再次干预。在过去十年中，人们付出了巨大努力来成功预防或治疗再狭窄，但尚未发现任何药物治疗方法在临床情况下足够有效。应对再狭窄的新策略是通过局部应用电离辐射，这在动物实验中可显著减少血管成形术后的细胞增殖。初步临床试验表明，血管内放射治疗是治疗再狭窄的一种安全有效的方法。需要进行长期随访的随机多中心研究来支持这些早期结果。
