Ho S T, Wang J J, Liu H S, Hu O Y, Tzeng J I, Liaw W J
Department of Anesthesiology, National Denfense Medical Center/Tri-Service General Hospital, Kaohsiung, Taiwan, R.O.C.
Acta Anaesthesiol Sin. 1998 Jun;36(2):65-70.
The aim of this study was to evaluate the efficacy and side effects of PCA nalbuphine (intravenous) versus morphine on postoperative pain in Chinese gynecologic patients.
Sixty women undergoing abdominal hysterectomy or myomectomy under spinal anesthesia were enrolled into the investigation. Patients were randomly divided into 2 groups (n = 30 each). Group 1 received intravenous nalbuphine using PCA device for the management of postoperative pain, whereas group 2 received PCA morphine for the same purpose. During the first 48 hours postoperatively, we collected the following data: analgesic doses, pain scores, vital signs, nausea, vomiting, pruritus and dizziness.
The results showed that despite different treatments, pain scores on day 1 and day 2 postoperatively were low and were not significantly different between groups. Meanwhile, the cumulative consumption of PCA nalbuphine (32 +/- 10 mg) and PCA morphine (30 +/- 9 mg) was similar. Both treatments showed only minor side effects and the incidence of each side effect was not significant between groups.
Both PCA nalbuphine and morphine are effective in the treatment of postoperative pain in Chinese gynecologic patients undergoing hysterectomy or myomectomy after spinal anesthesia and the potency of nalbuphine is similar to that of morphine.
本研究旨在评估静脉注射纳布啡自控镇痛（PCA）与吗啡用于中国妇科患者术后镇痛的疗效及副作用。
60例行脊髓麻醉下腹部子宫切除术或子宫肌瘤切除术的女性纳入本研究。患者随机分为2组（每组n = 30）。第1组使用PCA装置静脉注射纳布啡用于术后疼痛管理，而第2组使用PCA吗啡用于相同目的。术后前48小时，我们收集了以下数据：镇痛剂量、疼痛评分、生命体征、恶心、呕吐、瘙痒和头晕。
结果显示，尽管治疗方法不同，但术后第1天和第2天的疼痛评分较低，且两组之间无显著差异。同时，纳布啡PCA（32±10 mg）和吗啡PCA（30±9 mg）的累积用量相似。两种治疗方法均仅显示轻微副作用，且各副作用的发生率在两组之间无显著差异。
对于脊髓麻醉后行子宫切除术或子宫肌瘤切除术的中国妇科患者，纳布啡PCA和吗啡在术后疼痛治疗中均有效，且纳布啡的效力与吗啡相似。
