Aune A K, Lohmander S
Ortopedisk avdeling, Buskerud sentralsykehus, Drammen.
Tidsskr Nor Laegeforen. 1998 Oct 10;118(24):3785-90.
Osteoarthritis of the knee is not a well defined illness, but is a result of different causes that may lead to joint failure due to chondral damage, synovial inflammation, subchondral bone formation, and the formation of osteophytes along the joint lines. The pathogenesis is unclear. We still lack treatment to cure the early process of chondral degeneration. The treatment of choice in early and moderate osteoarthritis of the knee is limited to counselling, physiotherapy, analgesics, and surgical correction of malalignment. Documentation is still lacking on chondral debridement and transplantation of the degenerated cartilage by cultured chondrocytes, periosteum or perichondrium. An effective and well documented treatment of end-stage osteoarthritis of the knee in the older population is replacement of the joint by a knee prosthesis.
膝关节骨关节炎并非一种定义明确的疾病，而是由不同病因导致的结果，这些病因可能因软骨损伤、滑膜炎症、软骨下骨形成以及沿关节线形成骨赘而导致关节功能障碍。其发病机制尚不清楚。我们仍然缺乏治愈软骨退变早期过程的治疗方法。膝关节早期和中期骨关节炎的治疗选择仅限于咨询、物理治疗、镇痛药以及对线不良的手术矫正。关于软骨清创以及通过培养的软骨细胞、骨膜或软骨膜对退变软骨进行移植的文献仍然不足。对于老年人群终末期膝关节骨关节炎，一种有效且有充分文献记载的治疗方法是使用膝关节假体置换关节。
