Gold E W, Anderson L B, Schwartz E R, Miller C W
Prostaglandins. 1976 Nov;12(5):837-42. doi: 10.1016/0090-6980(76)90057-5.
Surgical inducement of medial instability in the right knee of rabbits was used to produce joint changes which resemble those observed in human osteoarthritis. Ordinary tap water was supplied to half of the rabbits and tap water plus sodium salicylate to the others. Determinations of prostaglandin were made on the synovial fluid and cartilage from all rabbits five months after surgery. In both groups, the concentration of prostaglandin in synovial fluid was lower in the operated knees, but the total amount of prostaglandin was found to be approximately equal to that in the unoperated knees. The development of degenerative joint changes therefore was not accompanied by increases in prostaglandin content. Salicylate treatment did not alter this observation, however, it did reduce overall prostaglandin levels. These results suggest that prostaglandin interaction is not involved in osteoarthritic joint degeneration.
通过手术诱导家兔右膝内侧不稳定，以产生类似于人类骨关节炎中观察到的关节变化。一半家兔供应普通自来水，另一半供应加有水杨酸钠的自来水。术后五个月，对所有家兔的滑液和软骨进行前列腺素测定。在两组中，手术侧膝关节滑液中前列腺素的浓度较低，但发现前列腺素的总量与未手术侧膝关节大致相等。因此，退行性关节变化的发展并未伴随着前列腺素含量的增加。然而，水杨酸盐治疗并未改变这一观察结果，但它确实降低了总体前列腺素水平。这些结果表明，前列腺素相互作用不参与骨关节炎性关节退变。
