Dekel S, Weissman S L
Acta Orthop Scand. 1978 Dec;49(6):519-28. doi: 10.3109/17453677808993232.
The effect of overuse and overuse combined with axial peak overloading on the knee joints of living rabbits has been investigated. A specially constructed apparatus was used for this purpose. Physical and biochemical changes are reported and include: 1. Early and progressive damage to the articular cartilage surface shown by the scanning electron microscope. 2. The presence of an increased amount of prostaglandin E in the synovial fluid. 3. A reduction of cyclic 3'--5' monophosphate in the subchondral bone. 4. Late changes which were consistent with osteoarthritis. These changes were found only in the joints subjected to simultaneous overuse and peak overloading. The results suggest that: 1. Cartilage damage and chemical changes in the subchondral bone are simultaneous and are both responsible for eventual degenerative changes. 2. Frictional overuse alone does not seem to be responsible for the production of oesteoarthritis.
已经对过度使用以及过度使用与轴向峰值过载相结合对活体兔膝关节的影响进行了研究。为此使用了专门构建的仪器。报告了物理和生化变化，包括：1. 扫描电子显微镜显示关节软骨表面早期和进行性损伤。2. 滑液中前列腺素E含量增加。3. 软骨下骨中环状3',5'-单磷酸减少。4. 与骨关节炎一致的晚期变化。这些变化仅在同时受到过度使用和峰值过载的关节中发现。结果表明：1. 软骨损伤和软骨下骨的化学变化是同时发生的，并且两者都是最终退行性变化的原因。2. 单独的摩擦性过度使用似乎不是骨关节炎产生的原因。
