Abe K, Otsuka Y, Yasujima M, Ciba S, Seino M, Irokawa N, Yoshinaga K
Prostaglandins. 1976 Nov;12(5):843-8. doi: 10.1016/0090-6980(76)90058-7.
The excretion rates of main urinary metabolite of PG F2alpha were measured radioimmunologically in 4 healthy persons and in 13 essential hypertensives. The resting values were 9.3+/-0.73 in the former and 10.4+/-2.17 ng/min in the latter. There was no significant differences between them. The excretion of the metabolite decreased prominently after the administration of furosemide. The percent decrease was 57% in healthy persons and 70% in essential hypertension. The percent result supports that furosemide inhibit the catabolism of PG F2alpha.
采用放射免疫法测定了4名健康人和13名原发性高血压患者尿中前列腺素F2α主要代谢产物的排泄率。前者静息值为9.3±0.73，后者为10.4±2.17 ng/min。两者之间无显著差异。服用速尿后，代谢产物的排泄显著减少。健康人减少百分比为57%，原发性高血压患者为70%。这一百分比结果支持速尿抑制前列腺素F2α的分解代谢。
