Lennkh C, Fischer P, Küfferle B, Kasper S
Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria.
Int Clin Psychopharmacol. 1998 Sep;13(5):225-8. doi: 10.1097/00004850-199809000-00006.
Trazodone, a triazolepyridine derivate, is both chemically and pharmacologically distinct from other serotonin reuptake inhibitors and possesses antidepressant, anxiolytic and hypnotic activity. We observed trazodone-induced delirium in three depressed patients who also suffered from preexisting organic cerebral lesions (two cases) or thyroideal dysfunction (one case). The appearance of hallucinations, psychomotoric agitation, and cognitive changes after initiation of trazodone therapy and their prompt cessation after drug discontinuation led to the impression that these were drug-induced phenomena. One possible hypothesis for the observed deliria is an oversensitivity to the effect of meta-chlorphenylpiperazine, which is a metabolite of trazodone with specific 5-HT agonistic properties.
曲唑酮是一种三唑吡啶衍生物，在化学和药理学上与其他5-羟色胺再摄取抑制剂不同，具有抗抑郁、抗焦虑和催眠活性。我们观察到3例抑郁症患者在服用曲唑酮后出现谵妄，这些患者同时还患有器质性脑损伤（2例）或甲状腺功能障碍（1例）。曲唑酮治疗开始后出现幻觉、精神运动性激越和认知改变，停药后这些症状迅速消失，这让人觉得这些是药物引起的现象。对于所观察到的谵妄，一种可能的假说是对间氯苯哌嗪的作用过度敏感，间氯苯哌嗪是曲唑酮的一种具有特定5-羟色胺激动特性的代谢产物。
