Bosma T J, Etherington J, O'Shea S, Corbett K, Cottam F, Holt L, Banatvala J E, Best J M
Department of Virology, St. Thomas' Hospital Campus, King's College London, London SE1 7EH, United Kingdom.
J Clin Microbiol. 1998 Dec;36(12):3524-6. doi: 10.1128/JCM.36.12.3524-3526.1998.
Synovial fluid samples and/or biopsies from 79 patients with various chronic inflammatory joint diseases or traumatic joint injury were tested for rubella virus (RV) in order to confirm or refute results from other studies that suggested RV as a cause of chronic inflammatory joint disease. Sixty-eight of the 72 patients tested had RV antibodies. RV RNA was detected by reverse transcription-PCR in the synovial fluid cells from two patients. RV was also isolated by cell culture from the synovial fluid of one of these two patients. This patient was a 42-year-old female with common variable immune deficiency and Mycoplasma hominis arthritis, while the other was a 68-year-old female with rheumatoid arthritis. While these results fail to confirm that RV is associated with chronic inflammatory joint disease, they suggest that RV may persist within a joint and be reactivated when cell-mediated immunity is suppressed.
为了证实或反驳其他研究中提出风疹病毒（RV）是慢性炎症性关节病病因的结果，对79例患有各种慢性炎症性关节病或创伤性关节损伤的患者的滑液样本和/或活检组织进行了风疹病毒检测。72例接受检测的患者中有68例存在RV抗体。通过逆转录聚合酶链反应在两名患者的滑液细胞中检测到RV RNA。还通过细胞培养从这两名患者之一的滑液中分离出RV。该患者是一名42岁患有常见可变免疫缺陷和人型支原体关节炎的女性，另一名是68岁患类风湿性关节炎的女性。虽然这些结果未能证实RV与慢性炎症性关节病有关，但表明RV可能在关节内持续存在，并在细胞介导的免疫受到抑制时被重新激活。
