普萘洛尔对大鼠脑去甲肾上腺素的体外作用。
Effect of propranolol on rat brain norepinephrine in vitro.
作者信息
Ziance R J
出版信息
Res Commun Chem Pathol Pharmacol. 1976 Oct;15(2):361-4.
PMID:981791
Abstract
At a 10(-5) to 10(-3) molar concentration range, 1-, d1- and d-propranolol were equipotent to progressively inhibit the uptake of 3H-NE into chopped rat cerebral cortex tissue. Similar concentrations of 1- and d1-, but not d-, propranolol significantly increased the amount of total deaminated catabolites (deaminated, deaminated-O-methylated) of 3H-NE; however, 10(-3) molar 1-, d1- and d-propranolol were required to increase the release of 3H-NE from rat brain in vitro.
摘要
在10⁻⁵至10⁻³摩尔浓度范围内，左旋普萘洛尔、消旋普萘洛尔和右旋普萘洛尔在逐渐抑制³H-去甲肾上腺素摄取进入切碎的大鼠大脑皮层组织方面具有同等效力。左旋普萘洛尔和消旋普萘洛尔的类似浓度，但右旋普萘洛尔则不然，能显著增加³H-去甲肾上腺素的总脱氨基代谢产物（脱氨基、脱氨基-O-甲基化）的量；然而，在体外，需要10⁻³摩尔的左旋普萘洛尔、消旋普萘洛尔和右旋普萘洛尔才能增加³H-去甲肾上腺素从大鼠脑内的释放。
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