腺垂体发育与Pit-1/GHF-1转录因子
Anterior pituitary development and Pit-1/GHF-1 transcription factor.
作者信息
de la Hoya M, Vila V, Jiménez O, Castrillo J L
机构信息
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Spain.
出版信息
Cell Mol Life Sci. 1998 Oct;54(10):1059-66. doi: 10.1007/s000180050234.
Anterior pituitary differentiation is a well-established paradigm in mammalian organogenesis. PIT1/GHF1, a homoeotic gene, plays a key role in terminal pituitary differentiation. Recently, a new set of transcription factors involved in early pituitary differentiation have been identified: Lhx-3, Lhx-4, P-OTX and Prop1. A pituitary-specific transcriptional cascade regulating a developmental programme leads to the determination of the mature cell types.
腺垂体分化是哺乳动物器官发生中一个已确立的范例。同源异型基因PIT1/GHF1在垂体终末分化中起关键作用。最近，已鉴定出一组参与垂体早期分化的新转录因子：Lhx-3、Lhx-4、P-OTX和Prop1。一个调节发育程序的垂体特异性转录级联导致成熟细胞类型的确定。
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