Rapraeger A C, Ott V L
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53706, USA.
Curr Opin Cell Biol. 1998 Oct;10(5):620-8. doi: 10.1016/s0955-0674(98)80038-0.
The syndecan family of cell-surface heparan sulfate proteoglycans participate in multiple cell behaviors ranging from growth factor signaling to cell adhesion. Participation in these activities is dependent on specific binding interactions of their heparan sulfate chains and molecular interactions of their core proteins with cytoskeletal and signaling molecules. The highly conserved features of the core proteins have long suggested important functions, which are only now beginning to be understood. Recent advances point to important roles for the extracellular, transmembrane and cytoplasmic domains of the syndecan core proteins in the assembly of these proteoglycans into an intracellular cytoskeletal and signaling apparatus. The proteins display interactions that may be common among the different family members, as well as interactions that provide signaling capabilities that are specific to individual members.
细胞表面硫酸乙酰肝素蛋白聚糖的syndecan家族参与多种细胞行为，范围从生长因子信号传导到细胞粘附。参与这些活动取决于其硫酸乙酰肝素链的特异性结合相互作用以及其核心蛋白与细胞骨架和信号分子的分子相互作用。核心蛋白的高度保守特征长期以来暗示着重要功能，而这些功能直到现在才开始被理解。最近的进展表明，syndecan核心蛋白的细胞外、跨膜和细胞质结构域在将这些蛋白聚糖组装成细胞内细胞骨架和信号传导装置中发挥着重要作用。这些蛋白显示出不同家族成员之间可能共有的相互作用，以及提供特定于个别成员的信号传导能力的相互作用。
