Ader J L, Rostaing L
Laboratoire d'Explorations Fonctionnelles Rénales et Métaboliques, et Unité INSERM 388, Rangueil University Hospital, Toulouse, France.
Curr Opin Nephrol Hypertens. 1998 Sep;7(5):539-45. doi: 10.1097/00041552-199809000-00009.
At the end of an era of almost exclusive use of cyclosporin A, there have been significant advances in the understanding of its immunosuppressive effects, whereas there is still uncertainty about the mechanisms underlying its nephrotoxicity. The recently introduced FK-506, in spite of its undeniable clinical advantages, has subsequently been proved to have rather similar nephrotoxicity. This paper reviews recent data on cyclosporin A and FK-506 nephrotoxicity, with emphasis on: first, the haemodynamic, functional and structural features; second, the potential mediators; and third, the relationship with some immunosuppressive mechanisms involved to give insights into the pathophysiology.
在几乎独家使用环孢素A的时代结束时，人们对其免疫抑制作用的理解有了重大进展，而其肾毒性的潜在机制仍不明确。最近引入的FK-506，尽管具有不可否认的临床优势，但随后被证明具有相当类似的肾毒性。本文综述了关于环孢素A和FK-506肾毒性的最新数据，重点在于：第一，血流动力学、功能和结构特征；第二，潜在的介质；第三，与一些免疫抑制机制的关系，以便深入了解病理生理学。
