Sonnenberg G E, Kotchen T A
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA.
Curr Opin Nephrol Hypertens. 1998 Sep;7(5):551-5. doi: 10.1097/00041552-199809000-00011.
Insulin resistance may be associated with hypertension and additional cardiovascular disease risk factors. Troglitazone, a thiazolidinedione, is an insulin sensitizing agent that has recently been approved by the USA Food and Drug Administration for the treatment of type II diabetes. Thiazolidinediones and other agents that increase insulin sensitivity, and lipid lowering drugs attenuate the development of hypertension in animal models and in limited clinical studies.
胰岛素抵抗可能与高血压及其他心血管疾病风险因素相关。曲格列酮是一种噻唑烷二酮类药物，属于胰岛素增敏剂，最近已获美国食品药品监督管理局批准用于治疗II型糖尿病。噻唑烷二酮类药物及其他增加胰岛素敏感性的药物，还有降脂药物，在动物模型及有限的临床研究中可减缓高血压的发展。
