Brünger A T, Adams P D, Rice L M
Howard Hughes Medical Institute, Yale University, New Haven, CT 06511, USA.
Curr Opin Struct Biol. 1998 Oct;8(5):606-11. doi: 10.1016/s0959-440x(98)80152-8.
Macromolecular crystallographic refinement has recently been made more efficient by the use of cross-validated maximum likelihood targets and torsion-angle molecular dynamics simulated annealing. In combination with automated model building methods, the amount of manual intervention required to complete and refine a structure is greatly reduced.
近年来，通过使用交叉验证的最大似然目标和扭转角分子动力学模拟退火，大分子晶体学精修变得更加高效。结合自动模型构建方法，完成和精修一个结构所需的人工干预量大大减少。
