Hiromatsu Y, Ishibashi M, Miyake I, Nonaka K
Department of Medicine, Kurume University School of Medicine, Japan.
Eur J Nucl Med. 1998 Oct;25(10):1448-52. doi: 10.1007/s002590050322.
We studied the significance of technetium-99m tetrofosmin scintigraphy in patients with subacute thyroiditis (SAT). Six patients with SAT, who had painful goitre with thyrotoxicosis, underwent 99mTc-pertechnetate scintigraphy and 99mTc-tetrofosmin imaging during the acute and recovery stages of SAT. The thyroid uptake ratio of tetrofosmin was compared with the clinical parameters associated with SAT. 99mTc-pertechnetate scintigraphy showed markedly reduced uptake in the thyroid during the acute stage of SAT, suggesting that the appropriate metabolic pathway is not functioning. Conversely, 99mTc-tetrofosmin images showed diffuse increased uptake in the thyroid region on early and delayed imaging. Tetrofosmin images in the acute stage and in the recovery stage of SAT showed different clearance curves for tetrofosmin uptake. The uptake ratio assessed as thyroid uptake/background (T/B) correlated with the serum C-reactive protein concentration. In conclusion, 99mTc-tetrofosmin uptake may reflect the inflammatory process associated with SAT, and thus this tracer may have potential as a marker of disease activity and severity.
我们研究了锝-99m 替曲膦闪烁扫描术在亚急性甲状腺炎（SAT）患者中的意义。6 例患有伴有甲状腺毒症的疼痛性甲状腺肿的 SAT 患者，在 SAT 的急性期和恢复期接受了高锝酸盐-99mTc 闪烁扫描术和替曲膦-99mTc 显像。将替曲膦的甲状腺摄取率与 SAT 相关的临床参数进行比较。高锝酸盐-99mTc 闪烁扫描术显示 SAT 急性期甲状腺摄取明显减少，提示正常代谢途径未起作用。相反，替曲膦-99mTc 图像显示早期和延迟显像时甲状腺区域摄取弥漫性增加。SAT 急性期和恢复期的替曲膦图像显示替曲膦摄取的清除曲线不同。以甲状腺摄取/本底（T/B）评估的摄取率与血清 C 反应蛋白浓度相关。总之，替曲膦-99mTc 摄取可能反映与 SAT 相关的炎症过程，因此这种示踪剂可能具有作为疾病活动和严重程度标志物的潜力。
