Beránek M, Palicka V
Ustav klinické biochemie a diagnostiky Fakultní nemocnice, Hradec Králové.
Ceska Slov Farm. 1998 Sep;47(5):211-4.
A short review provides basic information about the influence of glycation of plasma proteins, as a complication of uncompensated diabetes mellitus, on binding parameters of drugs from various pharmacological groups. There are many facts about the influence of diabetes on binding sites of plasma proteins, but only a relation between the free fraction of sulphonamides and the degree of albumin glycation was described. Observed changes of free fractions of other drugs in diabetic patients are related rather to a competition of these drugs with free fatty acids or other endogenic metabolites for albumin binding sites than to glycation reaction itself. A current clinical status and results of biochemical and pharmacokinetic analyses are necessary for an objective survey of efficiency of pharmacological treatment in diabetic patients.
一篇简短综述提供了有关血浆蛋白糖基化（作为未代偿糖尿病的一种并发症）对来自不同药理学组药物结合参数影响的基本信息。关于糖尿病对血浆蛋白结合位点的影响有很多事实，但仅描述了磺胺类药物游离部分与白蛋白糖基化程度之间的关系。糖尿病患者中其他药物游离部分的观察到的变化与其说是与糖基化反应本身有关，不如说是与这些药物与游离脂肪酸或其他内源性代谢物竞争白蛋白结合位点有关。对于客观评估糖尿病患者药物治疗的疗效，当前的临床状况以及生化和药代动力学分析结果是必要的。
