类风湿关节炎男性患者血清催乳素水平升高。

High serum prolactin levels in men with rheumatoid arthritis.

作者信息

Mateo L, Nolla J M, Bonnin M R, Navarro M A, Roig-Escofet D

机构信息

Rheumatology Service and Hormone Unit (Biochemistry Department), Ciutat Sanitària i Universitària de Bellvitge, Barcelona, Spain.

出版信息

J Rheumatol. 1998 Nov;25(11):2077-82.

PMID:9818647

Abstract

OBJECTIVE

High prolactin (PRL) levels have been reported in systemic lupus erythematosus, Reiter's syndrome, and psoriatic arthritis. However, results of PRL investigations in rheumatoid arthritis (RA) are contradictory. We evaluated the PRL status in men with RA and the possible effect on bone mineral density (BMD).

METHODS

We studied 91 men with RA and 68 controls. PRL serum levels were analyzed under standardized conditions. Sex hormones (testosterone, androstenedione, and DHEAS) were also studied. BMD was analyzed at L2-L4 and the femoral neck by Hologic QDR1000. Comparative tests, linear correlations, and multiple regression analysis were performed.

RESULTS

Serum PRL levels were significantly higher in men with RA (249+/-162 mU/l) than in controls (189+/-85 mU/l) (p=0.0015). High PRL levels were significantly correlated with the duration of RA (r=0.23; p=0.01) and with functional stage according to the Steinbrocker classification (r=0.24; p=0.01). High PRL concentrations were not correlated with the low levels of androgens observed in males with RA. Femoral BMD showed a negative correlation with PRL concentrations (r=0.20; p=0.04). Nevertheless, PRL was not a significant determinant of BMD.

CONCLUSION

Men with RA have high serum PRL levels and concentrations increase with longer disease evolution and worse functional stage. Prolactin levels do not have a direct effect on BMD.

摘要

目的

系统性红斑狼疮、赖特综合征及银屑病关节炎患者中曾有高催乳素（PRL）水平的报道。然而，类风湿关节炎（RA）患者PRL检测结果相互矛盾。我们评估了男性RA患者的PRL状况及其对骨密度（BMD）的可能影响。

方法

我们研究了91例男性RA患者和68例对照者。在标准化条件下分析PRL血清水平。还研究了性激素（睾酮、雄烯二酮和硫酸脱氢表雄酮）。采用Hologic QDR1000对L2-L4和股骨颈进行骨密度分析。进行了比较检验、线性相关分析和多元回归分析。

结果

男性RA患者的血清PRL水平（249±162 mU/l）显著高于对照者（189±85 mU/l）（p = 0.0015）。高PRL水平与RA病程（r = 0.23；p = 0.01）以及根据斯坦布鲁克分类法的功能分期（r = 0.24；p = 0.01）显著相关。高PRL浓度与RA男性患者中观察到的雄激素低水平无关。股骨骨密度与PRL浓度呈负相关（r = 0.20；p = 0.04）。然而，PRL并非骨密度的重要决定因素。