Trune D R, Leedy D A
Department of Otolaryngology-Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health Sciences University, Portland 97201, USA.
Laryngoscope. 1998 Nov;108(11 Pt 1):1729-32. doi: 10.1097/00005537-199811000-00025.
To distinguish potential autoimmune and nonautoimmune mechanisms underlying the salivary gland inflammation seen in Sjögren's syndrome and normal aging.
Immunohistochemical studies were conducted on the lacrimal and salivary glands of 2- and 5-month-old C3H.MRL-Faslpr autoimmune strain mice and age-matched C3H/HeJ nonautoimmune controls.
Glandular inflammatory foci, interstitial areas, and vasculature were stained for immunoglobulin G (IgG), immunoglobulin A (IgA), and complement to determine differences in their local immune parameter. Differences between the two strains were compared for immune changes attributable to autoimmune disease and between the two normal groups for normal aging changes.
Greater staining of IgG, IgA, and complement occurred in the inflammatory foci and interstitial areas of 5-month-old C3H.MRL-Faslpr lacrimal and submandibular glands compared with 5-month-old controls. Normal mice showed some increased immunoglobulin staining with aging, but little or no complement in any glands.
These differential findings suggest that the systemic autoimmune disease plays a more direct role in focal glandular inflammation in Sjögren's syndrome, whereas less severe immune mechanisms are involved in the inflammation of normal glands.
区分干燥综合征和正常衰老过程中唾液腺炎症潜在的自身免疫和非自身免疫机制。
对2月龄和5月龄的C3H.MRL-Faslpr自身免疫品系小鼠以及年龄匹配的C3H/HeJ非自身免疫对照小鼠的泪腺和唾液腺进行免疫组织化学研究。
对腺性炎症灶、间质区域和脉管系统进行免疫球蛋白G（IgG）、免疫球蛋白A（IgA）和补体染色，以确定其局部免疫参数的差异。比较两个品系之间因自身免疫性疾病导致的免疫变化，以及两个正常组之间正常衰老变化。
与5月龄对照小鼠相比，5月龄C3H.MRL-Faslpr小鼠泪腺和下颌下腺的炎症灶和间质区域中，IgG、IgA和补体的染色更强。正常小鼠随着年龄增长免疫球蛋白染色有所增加，但任何腺体中的补体很少或没有。
这些不同的结果表明，全身性自身免疫疾病在干燥综合征的局灶性腺体炎症中起更直接的作用，而正常腺体的炎症涉及的免疫机制不那么严重。
