Genetic contribution of the tumor necrosis factor region in Guillain-Barré syndrome.

作者信息

Ma J J, Nishimura M, Mine H, Kuroki S, Nukina M, Ohta M, Saji H, Obayashi H, Kawakami H, Saida T, Uchiyama T

机构信息

Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto, Japan.

出版信息

Ann Neurol. 1998 Nov;44(5):815-8. doi: 10.1002/ana.410440517.

We studied genetic polymorphisms in the tumor necrosis factor (TNF) region in 81 Japanese patients with Guillain-Barré syndrome (GBS) and 85 controls. A significantly higher frequency of the 100-base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNF alpha production, existed in Campylobacter jejuni-positive (Cj+) GBS patients than in controls, suggesting the involvement of a genetic predisposition to high TNF alpha secretion in the development of C. jejuni-related GBS.