Jiménez R, Burgos M
Departamento de Genética, Facultad de Ciencias, Universidad de Granada, Spain.
Bioessays. 1998 Sep;20(9):696-9. doi: 10.1002/(SICI)1521-1878(199809)20:9<696::AID-BIES2>3.0.CO;2-F.
Mammalian sex determination is controlled by the Y-linked gene SRY. Studies of sex-reversed patients and experimental data obtained with mice have identified other genes, such as DAX1, SOX9, SF1, and WT1, which take part in the process, and have suggested how these genes interact to determine the sex of a mammalian embryo. A recent paper in Nature by Swain et al. provides experimental data that basically confirm the previously proposed hypothesis that SRY acts by inhibiting the action of DSS/DAX1, which is a repressor of genes of the male pathway.
哺乳动物的性别决定由Y染色体连锁基因SRY控制。对性反转患者的研究以及用小鼠获得的实验数据已鉴定出其他参与该过程的基因，如DAX1、SOX9、SF1和WT1，并提示了这些基因如何相互作用以决定哺乳动物胚胎的性别。Swain等人近期发表在《自然》杂志上的一篇论文提供的实验数据基本证实了先前提出的假说，即SRY通过抑制DSS/DAX1的作用来发挥功能，而DSS/DAX1是雄性发育途径中基因的一种阻遏物。
