Yamada H, Yudate T, Orita T, Tezuka T
Department of Dermatology, Kinki University School of Medicine, Osaka, Japan.
J Clin Lab Immunol. 1996;48(4):167-75.
We investigated the role of Staphylococcus aureus-specific IgE in patients with atopic dermatitis (AD). The titer of serum S. aureus-specific IgE was measured using the RAST method in 67 patients with AD and correlated with serum LDH, eosinophil count and total IgE. The titer of S. aureus-specific IgE was elevated in 41 patients but was not detected in 26 patients. The mean serum level of total IgE was higher in the positive group than in the negative group, but the eosinophil count and LDH levels were not different between the two groups. S. aureus was detected and cultured from the skin of 33/41 (80%) patients in the positive group, but only from the skin of 5/26 (19%) patients of the negative group. Our results suggest that S. aureus-specific antibody is present in patients with moderate-to-severe atopic dermatitis and may be involved in the pathogenesis of AD.
我们研究了金黄色葡萄球菌特异性IgE在特应性皮炎（AD）患者中的作用。采用放射性变应原吸附试验（RAST）方法测定了67例AD患者血清中金黄色葡萄球菌特异性IgE的滴度，并将其与血清乳酸脱氢酶（LDH）、嗜酸性粒细胞计数及总IgE进行相关性分析。41例患者的金黄色葡萄球菌特异性IgE滴度升高，26例患者未检测到。阳性组血清总IgE平均水平高于阴性组，但两组嗜酸性粒细胞计数及LDH水平无差异。阳性组41例患者中有33例（80%）皮肤检测到并培养出金黄色葡萄球菌，而阴性组26例患者中只有5例（19%）皮肤检测到该菌。我们的结果表明，中重度特应性皮炎患者体内存在金黄色葡萄球菌特异性抗体，其可能参与了AD的发病机制。
