Greco P, Resta M, Vimercati A, Dicuonzo F, Loverro G, Vicino M, Selvaggi L
Institute of Obstetrics and Gynecology, University of Bari, Italy.
Ultrasound Obstet Gynecol. 1998 Oct;12(4):276-9. doi: 10.1046/j.1469-0705.1998.12040276.x.
Lissencephaly (agyria) is a cortical dysplasia associated with a disturbance in the migration of neocortical neurons. Because of abnormal sonographic findings in the brain of a 24-week fetus, we carried out serial magnetic resonance imaging (MRI) examinations which raised the suspicion of isolated lissencephaly. In the second trimester, an area of damage depicted as low-intensity signals was identified by MRI inside the cortical parenchyma. In the same cortical area, agyria was detected later in pregnancy, and postnatally calcification was observed by computerized tomography (CT) scan. We believe that ultrasound and targeted MRI examination can improve our understanding of some disorders of neuronal migration and that earlier diagnosis is feasible if both methods are employed and interpreted by sound criteria.
无脑回畸形（agyria）是一种与新皮质神经元迁移紊乱相关的皮质发育异常。由于在一名24周胎儿的脑部超声检查发现异常，我们进行了系列磁共振成像（MRI）检查，这引发了孤立性无脑回畸形的怀疑。在孕中期，MRI在皮质实质内发现一个表现为低强度信号的损伤区域。在同一皮质区域，孕期后期检测到无脑回畸形，出生后通过计算机断层扫描（CT）观察到钙化。我们认为，超声和针对性MRI检查可增进我们对某些神经元迁移障碍的理解，并且如果同时采用这两种方法并依据合理标准进行解读，早期诊断是可行的。
