Riska H, Mattson K, Kock B, Forsström J
Scand J Respir Dis. 1976;57(4):183-9.
A clinical presentation is made of a 2-3 year follow-up of six cases of acute renal failure that have been reported earlier. The patients had developed transient renal failure after the intermittent administration of rifampicin. The stage of olig-anuria lasted for 1-3 weeks, and five of the patients were treated by hemodialysis. Two of the patients died due to unrelated causes during the follow-up period. The four patients re-examined were clinically cured. Pathologic findings by light microscopy and immunofluorescence at biopsy were scarce. Nothing abnormal was seen by electron microscopy in two of the cases studied. Renal function was normal. In three cases the excretion at 131I-hippuran renography was slightly slowed. Although in the acute stage the renal lesions histologically appeared toxic, evidence suggestive of an immunological mechanism cannot be excluded.
本文对先前报道的6例急性肾衰竭患者进行了2 - 3年的随访。这些患者在间歇性服用利福平后出现了短暂性肾衰竭。少尿期持续1 - 3周，其中5例患者接受了血液透析治疗。2例患者在随访期间因无关原因死亡。重新检查的4例患者临床治愈。活检时光镜和免疫荧光检查的病理结果较少。在研究的2例病例中，电镜未见异常。肾功能正常。3例患者131I - 马尿酸肾图排泄略有减慢。虽然在急性期肾病变在组织学上表现为中毒性，但不能排除免疫机制的证据。
