Bridger J M, Bickmore W A
MRC Human Genetics Unit, Edinburgh, UK.
Trends Genet. 1998 Oct;14(10):403-9. doi: 10.1016/s0168-9525(98)01572-8.
The first complete genomic sequence of a eukaryote (Saccharomyces cerevisiae) has already been accomplished. It is estimated that the sequence of the human genome will be known early in the next millennium. Yet it is already apparent that, despite their immense length, these linear primary sequence maps will be inadequate descriptions of the eukaryotic genome, be it of a budding yeast or a human. To reflect our growing awareness of the importance of spatial context in chromosome function and in gene expression we argue that a more complete map of the genome should seek to embody the richness of information that we expect of the maps we use to navigate our way around the outside world.
真核生物（酿酒酵母）的首个完整基因组序列已经完成。据估计，人类基因组序列将在下个千年初为人所知。然而，显而易见的是，尽管这些线性一级序列图谱长度惊人，但对于真核生物基因组（无论是出芽酵母还是人类的基因组）而言，它们的描述并不充分。为了反映我们日益认识到的空间背景在染色体功能和基因表达中的重要性，我们认为，一个更完整的基因组图谱应设法体现出我们期望用于在外部世界导航的地图所具有的丰富信息。
