Chudek J, Schullerus D, Wilhelm M, Kovacs G
Department of Urology, Ruprecht-Karls-University, Heidelberg, Germany.
Br J Cancer. 1998 Nov;78(9):1162-4. doi: 10.1038/bjc.1998.647.
We demonstrate the constitutive expression of interleukin 6 (IL-6), IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha) and epidermal growth factor receptor (EGFR) in normal kidney cells, and in the majority of renal oncocytomas, papillary and non-papillary renal cell carcinomas (RCCs) by reverse transcriptase polymerase chain reaction (RT-PCR) technique. No expression of IL-6 and TGF-alpha and variable expression of GM-CSF, IL-8, EGF and EGFR was seen in chromophobe RCCs. The lack of expression of IL-6 and TGF-alpha might be correlated with the growth pattern, poor vascularity and low malignancy of chromophobe RCCs.
我们通过逆转录聚合酶链反应（RT-PCR）技术，证实了白细胞介素6（IL-6）、IL-8、粒细胞巨噬细胞集落刺激因子（GM-CSF）、表皮生长因子（EGF）、转化生长因子α（TGF-α）和表皮生长因子受体（EGFR）在正常肾细胞以及大多数肾嗜酸细胞瘤、乳头状和非乳头状肾细胞癌（RCC）中的组成性表达。在嫌色性肾细胞癌中未观察到IL-6和TGF-α的表达，GM-CSF、IL-8、EGF和EGFR的表达则有所不同。IL-6和TGF-α的表达缺失可能与嫌色性肾细胞癌的生长模式、血管生成不良和低恶性程度相关。
