Osono E, Kurihara S, Hayama N, Sakurai Y, Ohwada K, Onoda N, Takeuchi M, Tomizawa T, Komaba Y, Hashimoto K, Matsunobu S, Yoneshima H, Iino Y
Department of Nephrology and Cardiology, Kasukabe Shuwa Hospital, Saitama, Japan.
Am J Kidney Dis. 1998 Nov;32(5):725-30. doi: 10.1016/s0272-6386(98)70126-x.
We studied the relationship between polymorphism in intron 16 of the angiotensin-converting enzyme (ACE) gene and left ventricular (LV) hypertrophy in uremic patients treated with hemodialysis therapy. The LV parameters were not different for age-, hematocrit-, and blood pressure-matched patients in DD, ID, and II genotype groups. The most important factor for LV hypertrophy was systolic blood pressure, which correlated with the posterior wall thickness (r=0.35; P=0.001) and LV mass index (LVMI; r=0.23; P=0.032). Among nonhypertensive patients, the frequency of interventricular septum (IVS) hypertrophy (>12 mm) and hypertrophy in LVMI (>145 g/m2) was significantly greater in patients with the DD genotype than in I allele-positive (+) patients. The odds rate for IVS hypertrophy was 5.04 (95% confidence interval, 1.15 to 24.8). These data suggest that the DD genotype of the ACE gene polymorphism is a contributory factor for the development of LV hypertrophy in patients with end-stage renal disease (ESRD).
我们研究了血管紧张素转换酶（ACE）基因第16内含子多态性与接受血液透析治疗的尿毒症患者左心室（LV）肥厚之间的关系。在DD、ID和II基因型组中，年龄、血细胞比容和血压匹配的患者的左心室参数并无差异。左心室肥厚的最重要因素是收缩压，它与后壁厚度相关（r = 0.35；P = 0.001）以及左心室质量指数（LVMI；r = 0.23；P = 0.032）。在非高血压患者中，DD基因型患者的室间隔（IVS）肥厚（> 12 mm）和左心室质量指数肥厚（> 145 g/m²）的发生率显著高于I等位基因阳性（+）患者。室间隔肥厚的优势比为5.04（95%置信区间，1.15至24.8）。这些数据表明，ACE基因多态性的DD基因型是终末期肾病（ESRD）患者左心室肥厚发生的一个促成因素。
