胆囊收缩素拮抗剂与GABA激动剂在甩尾试验中诱导的抗伤害感受之间的相互作用。

Interactions between antinociception induced by cholecystokinin antagonists and GABA agonists in the tail-flick test.

作者信息

Zarrindast M R, Rezayat M, Ghanipoor N, Parvini S

机构信息

Department of Pharmacology, School of Medicine Tehran University of Medical Science, Iran.

出版信息

Pharmacol Toxicol. 1998 Oct;83(4):143-8. doi: 10.1111/j.1600-0773.1998.tb01460.x.

DOI:10.1111/j.1600-0773.1998.tb01460.x

PMID:9820874

Abstract

In this work, the influences of cholecystokinin receptor antagonists L-365,260, MK-329 and proglumide on antinociception induced by baclofen and GABA uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (THPO) in the tail flick test has been studied. Baclofen and THPO induced antinociception in the tail flick test. Morphine, and the CCK receptor antagonists, MK-329, L-365,260 and proglumide also induced antinociception. The CCK receptor antagonists potentiated antinociceptive response induced by both baclofen and THPO. It may be concluded that cholecystokinin receptor mechanism(s) may interact with antinociception induced by GABA receptor mechanism(s).

摘要

在本研究中，已对胆囊收缩素受体拮抗剂L-365,260、MK-329和丙谷胺在甩尾试验中对巴氯芬和γ-氨基丁酸（GABA）摄取抑制剂4,5,6,7-四氢异恶唑并[4,5-c]吡啶-3-醇（THPO）诱导的抗伤害感受的影响进行了研究。巴氯芬和THPO在甩尾试验中诱导了抗伤害感受。吗啡以及CCK受体拮抗剂MK-329、L-365,260和丙谷胺也诱导了抗伤害感受。CCK受体拮抗剂增强了巴氯芬和THPO诱导的抗伤害感受反应。可以得出结论，胆囊收缩素受体机制可能与GABA受体机制诱导的抗伤害感受相互作用。