Suzuki K, Nakazato H, Matsumoto K, Kurokawa K, Suzuki T, Suzuki K, Yamanaka H
Department of Urology, School of Medicine, Gunma University, Maebashi, Japan.
Int Urol Nephrol. 1998;30(4):487-91. doi: 10.1007/BF02550230.
To assess the tumour aggressiveness of teratoma, clinical records of patients with non-seminomatous germ cell testicular cancer were reviewed. Teratomatous elements were found in 57.8% of tumours. The rate of stage I tumours was lower in the teratoma-positive group than in the teratoma-negative group. Lymph node metastasis occurred more frequently than haematogenous metastasis in the teratoma-positive group. Tumour marker response in metastatic stage of teratoma-positive group was very excellent. Even if the radiographic response was not good, most patients were alive without disease after postchemotherapeutic salvage surgery. Furthermore, two patients with pure teratoma, who had tumour recurrence, were successfully treated with the multimodal therapy. Considering the smaller number of stage I patients in the teratoma-positive group than in the teratoma-negative group, the excellent overall response in the teratoma-positive group showed less aggressiveness of the tumour as a whole.
为评估畸胎瘤的肿瘤侵袭性，我们回顾了非精原细胞性睾丸生殖细胞癌患者的临床记录。57.8%的肿瘤中发现了畸胎瘤成分。畸胎瘤阳性组I期肿瘤的发生率低于畸胎瘤阴性组。在畸胎瘤阳性组中，淋巴结转移比血行转移更常见。畸胎瘤阳性组转移期的肿瘤标志物反应非常好。即使影像学反应不佳，大多数患者在化疗后挽救性手术后仍无病存活。此外，两名纯畸胎瘤复发患者经多模式治疗成功治愈。考虑到畸胎瘤阳性组I期患者数量少于畸胎瘤阴性组，畸胎瘤阳性组良好的总体反应表明肿瘤整体侵袭性较低。
