Asanuma F, Yamada Y, Kawamura E, Lee K, Kobayashi H, Yamada T, Suzuki T, Kubota T
Department of Surgery, Kitasato Institute Hospital, Tokyo, Japan.
Folia Microbiol (Praha). 1998;43(5):473-4. doi: 10.1007/BF02820793.
The antitumor effect of paclitaxel, epirubicin, and both in combination was tested using R-27, an estrogen receptor-positive human breast carcinoma. In an in vivo study using nude mice both drugs showed an additive effect, whereas they showed a supraadditive pattern in in vitro MTT assay. The combination of paclitaxel and epirubicin may enhance the antitumor effect on breast carcinoma.
使用雌激素受体阳性的人乳腺癌细胞系R-27测试了紫杉醇、表柔比星以及二者联合使用的抗肿瘤效果。在一项使用裸鼠的体内研究中，两种药物均显示出相加作用，而在体外MTT试验中它们呈现出超相加模式。紫杉醇与表柔比星联合使用可能增强对乳腺癌的抗肿瘤效果。
