头孢他啶在水溶液中的降解机制。
The mechanism of ceftazidime degradation in aqueous solutions.
作者信息
Zajac M, Siwek J, Muszalska I
机构信息
Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
出版信息
Acta Pol Pharm. 1998 Jul-Aug;55(4):275-8.
PMID:9821392
Abstract
Degradation of ceftazidime in aqueous solutions was studied at 298 K in acidic, basic and neutral conditions. The subsequent stage of hydrolysis involved the hydrolysis of the group at C-3, opening of the beta-lactam ring, and epimerization at C-6 or C-7. The decomposition of ceftazidime and the formation and identification of product C (pyridine) was followed by HPLC.
摘要
在298K下，研究了头孢他啶在酸性、碱性和中性条件下于水溶液中的降解情况。水解的后续阶段包括C-3位基团的水解、β-内酰胺环的开环以及C-6或C-7位的差向异构化。通过高效液相色谱法跟踪头孢他啶的分解以及产物C（吡啶）的形成和鉴定。
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