具有预期抗焦虑活性的新型1-甲基-5-氧代双环[2.2.1]庚烷-2,3-二甲酰亚胺的N-[4-(4-芳基和4-杂芳基-1-哌嗪基)丁基]衍生物的合成
Synthesis of new N-[4-(4-aryl- and 4-heteroaryl-1-piperazinyl)butyl]derivatives of 1-methyl-5-oxobicyclo[2.2.1]heptane-2,3-dicarboximide with an expected anxiolytic activity.
作者信息
Kossakowski J, Zawadowski T, Kuśmierczyk J
机构信息
Department of Medical Chemistry, Medical University of Warsaw, Poland.
出版信息
Acta Pol Pharm. 1998 Jul-Aug;55(4):315-8.
PMID:9821397
Abstract
Preparation of a number of derivatives of 1-methyl-5-oxobicyclo[2.2.1]heptane-2,3-dicarboximide with a potential anxiolytic activity has been described. New analogs of Tandospirone i.e. derivatives of bicyclo[2.2.1]heptane (10), were aimed at.
摘要
已经描述了一系列具有潜在抗焦虑活性的1-甲基-5-氧代双环[2.2.1]庚烷-2,3-二甲酰亚胺衍生物的制备。目标是坦度螺酮的新类似物，即双环[2.2.1]庚烷（10）的衍生物。
Zotero 插件