Ogiso M
Cell and Information, PRESTO, Japan Science and Technology Corporation.
Acta Biochim Pol. 1998;45(2):501-7.
Mammalian lens contains Lewis(x), sialyl-Lewis(x) and alpha-galactosyl epitopes in neolactoseries glycosphingolipids. The expression of these three epitopes is not observed in lens epithelial cells, but is immunohistochemically detected in the inner cortical fibers and the lens nucleus. In embryonic chick lens, sialyl-Lewis(x)-containing gangliosides were also detected in the transitional zone and elongating lens fibers. Thus, the Lewis(x), sialyl-Lewis(x) and alpha- galactosyl epitopes may be associated with the differentiation and maturation of lens epithelial cells to lens fibers.
哺乳动物晶状体在新乳糖系列糖鞘脂中含有Lewis(x)、唾液酸化Lewis(x)和α-半乳糖基表位。在晶状体上皮细胞中未观察到这三种表位的表达，但在内皮质纤维和晶状体核中可通过免疫组织化学检测到。在胚胎鸡晶状体中，在过渡区和伸长的晶状体纤维中也检测到了含唾液酸化Lewis(x)的神经节苷脂。因此，Lewis(x)、唾液酸化Lewis(x)和α-半乳糖基表位可能与晶状体上皮细胞向晶状体纤维的分化和成熟有关。
