过氧化氢酶活性不同的小鼠和人类细胞中阿霉素诱导损伤的DNA修复
DNA repair of adriamycin induced damage in mouse and human cells differing in catalase activity.
作者信息
Gruber B M, Anuszewska E L
机构信息
Department of Vitamin Drugs, Drug Institute, Warsaw, Poland.
出版信息
Acta Biochim Pol. 1998;45(2):573-7.
PMID:9821885
Abstract
Catalase is known to counteract cytotoxic effect of adriamycin, used as an anti-neoplastic drug. In cells with low catalase activity no repair of adriamycin induced lesions was observed up to 48 h post treatment. In cells with high catalase activity after 48 h the repair was either complete or partial depending on the human or mouse cell type used.
摘要
过氧化氢酶已知可对抗作为抗肿瘤药物使用的阿霉素的细胞毒性作用。在过氧化氢酶活性低的细胞中，直至处理后48小时均未观察到阿霉素诱导损伤的修复。在过氧化氢酶活性高的细胞中，48小时后修复情况取决于所使用的人源或鼠源细胞类型，可能是完全修复或部分修复。
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